Palonosetron is a carbazole derivative and a selective serotonin receptor antagonist with antiemetic activity.
Palonosetron competitively blocks the action of serotonin at 5-hydroxytryptamine type 3 (5-HT3) receptors located on vagal afferents in the chemoreceptor trigger zone (CTZ), resulting in suppression of chemotherapy-induced nausea and vomiting.
| Product Name |
Palonosetron Hydrochloride |
| CAS Number |
135729-62-3 |
| Therapeutic Class |
Serotonin (5-HT3) receptor antagonist, Antiemetic |
| Dosage Form |
Solution for Injection, Oral Capsule |
| Availability |
Commercial |
| Regulatory Status |
USDMF, EDMF, JDMF |